This project links three groups of investigators at Weill Cornell (Schiff, ND, Purpura, KP), Rockefeller University (Pfaff, D) and Medical College of Wisconsin (Buston, C) under a multiple PI mechanism (Schiff, ND as Administrative PI) to develop an integrative research program modeling central thalamic brain stimulation as a therapeutic technique. Weill Cornell studies will include the effects of electrical stimulation of the central thalamus on frontal lobe activity during performance of cognitive tasks in the awake primate study. Rockefeller University work focuses on rodent studies of central thalamic brain stimulation in animal models of brain injury and the University of Wisconsin provides bioengineering support in modeling of applied electric field in the primate and rat thalamus.