This is a multi-center, multi-PI collaborative grant (Weill Cornell, Stanford University, Harvard/Spaulding, Cleveland Clinic, University of Utah) that aims to carry out a first-in-man feasibility study of central thalamic deep brain stimulation for the treatment of chronic cognitive impairment after severe-to-moderate brain injuries. The long-term goal of these studies is to establish a new therapeutic avenue for severely brain-injured patients and to develop a new device platform based on pre-clinical studies carried out under 1R01 NS067249.