Cognitive enhancement with central thalamic electrical stimulation.

TitleCognitive enhancement with central thalamic electrical stimulation.
Publication TypeJournal Article
Year of Publication2006
AuthorsShirvalkar, Prasad, Seth Malika, Schiff Nicholas D., and Herrera Daniel G.
JournalProc Natl Acad Sci U S A
Date Published2006 Nov 7
KeywordsAnimals, Cognition, Cognition Disorders, Early Growth Response Protein 1, Electric Stimulation Therapy, Gene Expression, Genes, fos, Immunohistochemistry, Male, Proto-Oncogene Proteins c-fos, Rats, Rats, Sprague-Dawley, Thalamus

Central thalamic electrical stimulation has been proposed as a method for remediation of acquired cognitive disability. Long-standing experimental and clinical observations indicate a key role for neurons within the central thalamus in maintaining the alert waking state and facilitating attended behaviors. Here, we show that continuous high frequency (100 Hz) electrical stimulation of the central thalamus generates widespread cortical activation of c-fos across all cortical layers and a selective pattern of regulation of zif268 within the supragranular, granular, and infragranular cortical laminae. Significant elevation of both immediate early genes also is seen in the dentate gyrus of the hippocampus. Use of the same stimulation parameters is shown to facilitate untrained goal-directed seeking behavior and object recognition memory in rodents. An overall increase of exploratory motor behaviors and grooming activity also is observed, consistent with a global increase in arousal. Taken together, these studies indicate that electrical stimulation of the central thalamus may enhance cognitive performance through neocortical and hippocampal neuronal activation and specific regulation of gene expression.

Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID17065322
PubMed Central IDPMC1622923

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