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Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.

TitleCommon resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.
Publication TypeJournal Article
Year of Publication2013
AuthorsWilliams, Shawniqua T., Conte Mary M., Goldfine Andrew M., Noirhomme Quentin, Gosseries Olivia, Thonnard Marie, Beattie Bradley, Hersh Jennifer, Katz Douglas I., Victor Jonathan D., Laureys Steven, and Schiff Nicholas D.
JournalElife
Volume2
Paginatione01157
Date Published2013
ISSN2050-084X
Abstract

Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6-10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7-0.8) within and between hemispheres. Zolpidem administration sharply reduces EEG power and coherence at these low frequencies. The ∼6-10 Hz activity is proposed to arise from intrinsic membrane properties of pyramidal neurons that are passively entrained across the cortex by locally-generated spontaneous activity. Activation by zolpidem is proposed to arise from a combination of initial direct drug effects on cortical, striatal, and thalamic populations and further activation of underactive brain regions induced by restoration of cognitively-mediated behaviors. DOI: http://dx.doi.org/10.7554/eLife.01157.001.

DOI10.7554/eLife.01157
Alternate JournalElife
PubMed ID24252875
PubMed Central IDPMC3833342

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