Consciousness: its neurobiology and the major classes of impairment.

TitleConsciousness: its neurobiology and the major classes of impairment.
Publication TypeJournal Article
Year of Publication2011
AuthorsGoldfine, Andrew M., and Schiff Nicholas D.
JournalNeurol Clin
Date Published2011 Nov
KeywordsBrain, Consciousness, Consciousness Disorders, Humans, Neural Pathways, Neurobiology

Human consciousness requires brainstem, basal forebrain, and diencephalic areas to support generalized arousal, and functioning thalamocortical networks to respond to environmental and internal stimuli. Disconnection of these interconnected systems, typically from cardiac arrest and traumatic brain injury, can result in disorders of consciousness. Brain injuries can also result in loss of motor output out of proportion to consciousness, resulting in misdiagnoses. The authors review pathology and imaging studies and derive mechanistic models for each of these conditions. Such models may guide the development of target-based treatment algorithms to enhance recovery of consciousness in many of these patients.

Alternate JournalNeurol Clin
PubMed ID22032656
PubMed Central IDPMC3222861
Grant ListKL2 RR024997 / RR / NCRR NIH HHS / United States
KL2 RR024997-01 / RR / NCRR NIH HHS / United States
KL2RR024997 / RR / NCRR NIH HHS / United States
NICHD 51912 / / PHS HHS / United States
R01 HD051912-01A2 / HD / NICHD NIH HHS / United States

Weill Cornell Medicine Consortium for the Advanced Study of Brain Injury 520 East 70th Street New York, NY