| Title | Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Wheaton, Lewis A., Bohlhalter Stephan, Nolte Guido, Shibasaki Hiroshi, Hattori Noriaki, Fridman Esteban, Vorbach Sherry, Grafman Jordan, and Hallett Mark |
| Journal | Neurosci Lett |
| Volume | 433 |
| Issue | 2 |
| Pagination | 87-92 |
| Date Published | 2008 Mar 12 |
| ISSN | 0304-3940 |
| Keywords | Adult, Aged, Apraxia, Ideomotor, Cerebral Cortex, Electroencephalography, Functional Laterality, Humans, Middle Aged, Nerve Net, Neurodegenerative Diseases, Stroke |
| Abstract | We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage. |
| DOI | 10.1016/j.neulet.2007.12.065 |
| Alternate Journal | Neurosci. Lett. |
| PubMed ID | 18249498 |
| PubMed Central ID | PMC2276599 |
| Grant List | Z01 NS002669-23 / NS / NINDS NIH HHS / United States |
Submitted by mam2155 on January 7, 2014 - 10:53am