Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.

TitleKinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.
Publication TypeJournal Article
Year of Publication2010
AuthorsFridman, Esteban A., Crespo Marcos, Arg├╝ello Santiago Gomez, Degue Lorena, Villarreal Mirta, Bohlhalter Stephan, Wheaton Lewis, and Hallett Mark
JournalJ Neurol Neurosurg Psychiatry
Volume81
Issue4
Pagination423-7
Date Published2010 Apr
ISSN1468-330X
KeywordsBiomechanical Phenomena, Botulinum Toxins, Type A, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Agents, Spasm, Stroke, Upper Extremity
Abstract

Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.

DOI10.1136/jnnp.2009.188052
Alternate JournalJ. Neurol. Neurosurg. Psychiatr.
PubMed ID19965856
PubMed Central IDPMC3163597
Grant ListR01 NS046094-02 / NS / NINDS NIH HHS / United States
R01 NS046094-03 / NS / NINDS NIH HHS / United States

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