Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.

TitleKinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.
Publication TypeJournal Article
Year of Publication2010
AuthorsFridman, Esteban A., Crespo Marcos, Arg├╝ello Santiago Gomez, Degue Lorena, Villarreal Mirta, Bohlhalter Stephan, Wheaton Lewis, and Hallett Mark
JournalJ Neurol Neurosurg Psychiatry
Date Published2010 Apr
KeywordsBiomechanical Phenomena, Botulinum Toxins, Type A, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Agents, Spasm, Stroke, Upper Extremity

Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.

Alternate JournalJ. Neurol. Neurosurg. Psychiatr.
PubMed ID19965856
PubMed Central IDPMC3163597
Grant ListR01 NS046094-02 / NS / NINDS NIH HHS / United States
R01 NS046094-03 / NS / NINDS NIH HHS / United States

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