Title | Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Fridman, Esteban A., Crespo Marcos, Argüello Santiago Gomez, Degue Lorena, Villarreal Mirta, Bohlhalter Stephan, Wheaton Lewis, and Hallett Mark |
Journal | J Neurol Neurosurg Psychiatry |
Volume | 81 |
Issue | 4 |
Pagination | 423-7 |
Date Published | 2010 Apr |
ISSN | 1468-330X |
Keywords | Biomechanical Phenomena, Botulinum Toxins, Type A, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Agents, Spasm, Stroke, Upper Extremity |
Abstract | Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke. |
DOI | 10.1136/jnnp.2009.188052 |
Alternate Journal | J. Neurol. Neurosurg. Psychiatr. |
PubMed ID | 19965856 |
PubMed Central ID | PMC3163597 |
Grant List | R01 NS046094-02 / NS / NINDS NIH HHS / United States R01 NS046094-03 / NS / NINDS NIH HHS / United States |
Submitted by mam2155 on January 7, 2014 - 10:53am