Frequency-selective control of cortical and subcortical networks by central thalamus.

TitleFrequency-selective control of cortical and subcortical networks by central thalamus.
Publication TypeJournal Article
Year of Publication2015
AuthorsLiu, Jia, Lee Hyun Joo, Weitz Andrew J., Fang Zhongnan, Lin Peter, Choy ManKin, Fisher Robert, Pinskiy Vadim, Tolpygo Alexander, Mitra Partha, Schiff Nicholas, and Lee Jin Hyung
Date Published2015 Dec 10
KeywordsAnimals, Cerebral Cortex, Electric Stimulation, Electroencephalography, Models, Neurological, Neural Pathways, Neurons, Rats, Sprague-Dawley, Thalamus

Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG monitoring to characterize the central thalamus-driven global brain networks responsible for switching brain state. 40 and 100 Hz stimulations of central thalamus caused widespread activation of forebrain, including frontal cortex, sensorimotor cortex, and striatum, and transitioned the brain to a state of arousal in asleep rats. In contrast, 10 Hz stimulation evoked significantly less activation of forebrain, inhibition of sensory cortex, and behavioral arrest. To investigate possible mechanisms underlying the frequency-dependent cortical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations. Importantly, suppressing incertal activity during 10 Hz central thalamus stimulation reduced the evoked cortical inhibition. These findings identify key brain-wide dynamics underlying central thalamus arousal regulation.

Alternate JournalElife
PubMed ID26652162
PubMed Central IDPMC4721962
Grant ListR00EB008738 / EB / NIBIB NIH HHS / United States
R01 NS087159 / NS / NINDS NIH HHS / United States
R01MH087988 / MH / NIMH NIH HHS / United States
RF1 AG047666 / AG / NIA NIH HHS / United States
R01 NS091461 / NS / NINDS NIH HHS / United States
R01NS087159 / NS / NINDS NIH HHS / United States

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