Title | Illuminating Neural Circuits: From Molecules to MRI. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lee, Jin Hyung, Kreitzer Anatol C., Singer Annabelle C., and Schiff Nicholas D. |
Journal | J Neurosci |
Volume | 37 |
Issue | 45 |
Pagination | 10817-10825 |
Date Published | 2017 11 08 |
ISSN | 1529-2401 |
Keywords | Animals, Brain, Humans, Magnetic Resonance Imaging, Molecular Imaging, Nervous System Diseases, Neural Pathways, Optogenetics |
Abstract | Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation. Finally, we discuss how optogenetic functional magnetic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of neurological diseases. |
DOI | 10.1523/JNEUROSCI.2569-17.2017 |
Alternate Journal | J. Neurosci. |
PubMed ID | 29118210 |
PubMed Central ID | PMC5678014 |
Grant List | R01 NS064984 / NS / NINDS NIH HHS / United States R01 NS087159 / NS / NINDS NIH HHS / United States |
Submitted by jeh2015 on February 27, 2019 - 3:31pm