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Illuminating Neural Circuits: From Molecules to MRI.

TitleIlluminating Neural Circuits: From Molecules to MRI.
Publication TypeJournal Article
Year of Publication2017
AuthorsLee, Jin Hyung, Kreitzer Anatol C., Singer Annabelle C., and Schiff Nicholas D.
JournalJ Neurosci
Volume37
Issue45
Pagination10817-10825
Date Published2017 11 08
ISSN1529-2401
KeywordsAnimals, Brain, Humans, Magnetic Resonance Imaging, Molecular Imaging, Nervous System Diseases, Neural Pathways, Optogenetics
Abstract

Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation. Finally, we discuss how optogenetic functional magnetic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of neurological diseases.

DOI10.1523/JNEUROSCI.2569-17.2017
Alternate JournalJ. Neurosci.
PubMed ID29118210
PubMed Central IDPMC5678014
Grant ListR01 NS064984 / NS / NINDS NIH HHS / United States
R01 NS087159 / NS / NINDS NIH HHS / United States

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