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Large-scale brain dynamics in disorders of consciousness.

TitleLarge-scale brain dynamics in disorders of consciousness.
Publication TypeJournal Article
Year of Publication2014
AuthorsSchiff, Nicholas D., Nauvel Tanya, and Victor Jonathan D.
JournalCurr Opin Neurobiol
Volume25C
Pagination7-14
Date Published2014 Apr
ISSN1873-6882
Abstract

Brain injury profoundly affects global brain dynamics, and these changes are manifest in the electroencephalogram (EEG). Despite the heterogeneity of injury mechanisms and the modularity of brain function, there is a commonality of dynamical features that characterize the EEG along the gamut from coma to recovery. After severest injury, EEG activity is concentrated below 1Hz. In minimally conscious state during wakefulness, there is a peak of activity in the 3-7Hz range, often coherent across the brain, and often also activity in the beta (15-30Hz) range. These spectral changes likely result from varying degrees of functional deafferentation at thalamic and cortical levels. EEG-based indices of brain dynamics that go beyond these simple spectral measures may provide further diagnostic information and physiologic insights.

DOI10.1016/j.conb.2013.10.007
Alternate JournalCurr. Opin. Neurobiol.
PubMed ID24709594
Grant ListR01 HD051912 / HD / NICHD NIH HHS / United States

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