Quantitative descriptions of generalized arousal, an elementary function of the vertebrate brain.

TitleQuantitative descriptions of generalized arousal, an elementary function of the vertebrate brain.
Publication TypeJournal Article
Year of Publication2011
AuthorsQuinkert, Amy Wells, Vimal Vivek, Weil Zachary M., Reeke George N., Schiff Nicholas D., Banavar Jayanth R., and Pfaff Donald W.
JournalProc Natl Acad Sci U S A
Volume108 Suppl 3
Pagination15617-23
Date Published2011 Sep 13
ISSN1091-6490
KeywordsAnimals, Arousal, Brain, Humans, Hunger, Information Theory, Nonlinear Dynamics, Vertebrates
Abstract

We review a concept of the most primitive, fundamental function of the vertebrate CNS, generalized arousal (GA). Three independent lines of evidence indicate the existence of GA: statistical, genetic, and mechanistic. Here we ask, is this concept amenable to quantitative analysis? Answering in the affirmative, four quantitative approaches have proven useful: (i) factor analysis, (ii) information theory, (iii) deterministic chaos, and (iv) application of a Gaussian equation. It strikes us that, to date, not just one but at least four different quantitative approaches seem necessary for describing different aspects of scientific work on GA.

DOI10.1073/pnas.1101894108
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID21555568
PubMed Central IDPMC3176607
Grant ListHD-05751 / HD / NICHD NIH HHS / United States
MH-38273 / MH / NIMH NIH HHS / United States
R01 NS067249 / NS / NINDS NIH HHS / United States

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